Wednesday, October 30, 2019

Term Paper Project Domino's Pizza marketing strategist

Project Domino's Pizza marketing strategist - Term Paper Example o the increase in demand for fast food in the market and as a result of which new and existing pizza manufacturers have been entering or expanding their operations in the markets globally. It needs to be mentioned in this regard that the aspect of globalization also influenced Domino’s Pizza owing to which the company has been making constant attempts to enter or expand their operations in the new global markets. It was found in this respect that Domino’s intended to enter the markets of Argentina with their available or innovative fast foods such as pizza and drinks among others in order to realize their expansion plans. History and Origin of Domino’s Pizza Domino’s Pizza was introduced in the year 1960 and started operating in Michigan, United States by serving fast foods and deserts among others. Gradually, after capturing the market of US, the company started to expand its business overseas along with encompassing all the states of US. Presently, the c ompany is known to be operating in 70 countries with 10000 stores. Domino’s Pizza is considered to be amongst the largest chains of pizza restaurants currently owing to its global presence. Moreover, in the year 1998, the owner of Domino’s Pizza sold 93% of the company to Bain Capital Inc and in 2004, it transformed into a public company. Domino’s introduced innovative ideas with regard to their food products as well as services for the global market in order to satisfy the customers’ demands along with expanding the business operations. A few of the innovative food items introduced by the company can be identified as new inspired pizza, Domino’s heat wave, a desert food named cinna stix, cheesy dots and classic cheese burger among others. (Domino’s Pizza, 2012). It was recently found that Domino’s Pizza intends to enter the market of Argentina in order to fulfill its expansion plans. Demographic and Geographic Factors of Argentina Argentina is a European country and is learnt to be surrounded by Brazil, Uruguay, Paraguay and Chile along with Bolivia. Argentina includes 5 cities namely Buenos Aires, Cordoba, Rosario, Mendoza along with La Plata. The total population of Argentina is stated to be 37 million as per 2000 year census. The form of Argentina’s government can be ident ified as Federal Republic with Bicameral Legislative Power. The prevailing religion of Argentina is Roman Catholic and the languages spoken are Spanish along with other native tongues (Argentina Xplora, 2001). Internal and External Environmental Factors of Argentina The market trends of Argentina’s fast food sector reveals demands do exist in the market which marks and justifies the presence of certain companies such as KFC, McDonalds and others in the market. These stated companies have also been found to expand their business operations throughout the various markets of Argentina (Euromonitor, 2012). The rising demand for fast food in Argentina can be ascertained from the amount of fast food stores present in the country and also from the expansion plans of various

Monday, October 28, 2019

Structure of Myometrium Architecture

Structure of Myometrium Architecture THE STRUCTURAL AND ULTRASTRUCTURAL PARTICULARITIES OF THE MYOMETRIUM ARCHITECTURE Antonella Chescà ¤1, M.A.Moga1, Mariana Tilinca2, H. Matei3 Summary The morphological aspects of the human non-pregnant and pregnant at due time myometrium were emphasized by the classical histological technique and the electronic microscopic technique. We noticed the structural changes that appear at the level of the myocytes, connective and myometrial vascular structures. Both the stage of non-pregnant uterus and the one of pregnant uterus at due time present structural and ultra-structur ­al particularities at the level of the myocytes, connective structures and of the myometrial vascular ones. Key words: myometrium, myocytes, optical microscopy, electronic microscopy The myometrium is made up of smooth muscular fibers that are internally disposed in layers with circular fibers and externally with longitudinal fibers, in-between them being a layer of coiled fibers that, during the pregnancy, allow the uterus to grow and to be properly irrigated with blood. The myometrium is crossed by numerous blood vessels, with predominant venous type structures, also known as stratum vasculosum. It was ascertained that the uterine smooth muscular fibers play a major role in the physiologic haemostasis, namely in closing the vascular structures at this level. (5) During the pregnancy both the uterine body and the cervix become violaceae, due to the strong blood irrigation. The pregnancy is featured by the hypertrophy and the hyper ­plasia of the myometrium. We may also notice an increase of the number of elastic and collagen fibers that prevent the uterine wall from breaking. The changes of the cervix are less representative and consist of edema and local congestion. (4) The normal evolution of the pregnancy takes place on the grounds of certain important transformations of the endocrine system. Besides the changes appearing at the level of the genital tract generated by the development of the embryo and of the fetus, the body of the pregnant woman will undergo a stage of more intense hormone activity. (3) The investigations were made on human fresh material taken by the specialty services of obstetrics-gynecology, with the contribution of the anatomical pathology service within Dr. I. A. Sbarcea Hospital of Brasov and of the specialized study laboratories of the Cellular and Molecular Medicine Department within Carol Davila Medical University of Bucharest. The fragments of the normal non-pregnant uterus were obtained from surgeries such as total and subtotal hysterectomies. The fragments of normal pregnant uterus at due time were taken both from the uterine body and from the cervix. The fragments taken within the specialty services were studied by means of the classical optic microscopy method and by means of the electronic microscopy. The classic histological technique used the hematoxylin- eosin and Van Gieson staining. The fragments taken for examination by means of the electronic microscope were processed according to the technique that includes as main stages the fixation with glutaraldehyde in cacodyl pad for 90 minutes at 4C, washing with cacodyl pad pH 7.4, three times for 5 minutes at 4 °C; incubation in GOMORI environment; postfixacion in 0s04 of 1%, for 90 minutes at 4 °C; rinsing in bidistilled water three time for 5 minutes each, at room temperature, block coloring in uranyl acetate for 30 minutes, at 4C in the dark, washing with 10% alcohol, twice, 3 minutes each, at room temperature; dehydration with propdenoxide, twice for 5 minutes each at room temperature; dehydration with absolute ethylic alcohol, 3 times. 5 minutes each at room temperature; dehydration with propilenoxide twice, 5 minutes each at room temperature; penetration in Epon with inclusion in propilenoxide (1:1), for minimum one hour, followed by the evaporation of propilenoxide, up to 8 hours, penetration with Epon inc lusion for 2 hours, inclu ­sion, ultra sectioning at microtoms, grids contrasting and grids examination at the electronic microscope, obtaining magnifications between lOOOxoOOOx according to Onicescu method, 1998. We monitored the structural and ultra structural changes appearing in the uterine muscular fibers, in the connective structures at this level, as well as of the vascular myometrial structures using classical histological and electronic microscopy techniques. Ultra structurally, the uterine muscular fiber presents features common to the smooth muscular fibers of the cavity organs, with a centrally located, elongated nucleus. The sarcolemma of the myocytes located at the periphery of the muscle fiber seems to have three layers. The changes appeared at the level of the sarcoplasma may be grouped in two areas. At the level of the central area, the changes of the common organelles are being emphasized, such as the rough endoplasmic reticulum made up of several cisterns and vacuoles, of whose membranes ribosomes are being attached at large intervals, free ribosomes and glycogen inclusions, rare flattened sacks and mitochondria presenting a small number of lamella-form christa. At the level of the peripheral area that occupies the larger part, are the special, organelles, forming the contrac ­tile sublayers of the uterine muscular fiber, namely the myofilaments and the dense bodies. The myofilaments, visible at the electronic microscope, are represented only by actin filaments corresponding to the thin filaments of the striated muscle fiber. The myosin filaments are missing, corresponding to the thick filaments of the striated muscle fiber. We noticed ultra structural changes of the uterine muscular fiber, where the myosin appears as dense bodies, noticed as opaque spots, dense at electrons flow, elongated, distributed among the actin filaments. (12) During the pregnancy the myometrium hypertrophies, process that by its rapidity and amplitude, is a unique phenomenon in the normal adult body, accompanied by spectacular reshuffling of the uterine muscle fiber. In these circumstances, the myocytes grow of about 5-10 times, reaching lengths of 500 micrometers. In the same time, they keep their general shape, but elongations appear extensions especially at the ends. (7)Thus, major changes of the main components of the sarcoplasma are achieved. Both the myofilaments and the dense bodies numerically grow. Unlike the myocyte from the non pregnant uterus, the commune organelles occupy large areas in the sarcoplasma and in the peripheral area of the cell. The Golgi complex shows quantity and quality changes, becoming one of the most prominent features of the sarcoplasma. The quantity determinations showed an increase of the glycogen content of the pregnant uterine muscle fiber, of approximately 50 times. (5) Under the influence of the ovaries hormones, various kinds of muscle connections appear in the myometrium, characteristic to the effect of the estrogens or of the progesterone. Under the influence of the estrogen, we may simultane ­ously notice three types of distinct cell groups, light cells oriented approximately parallel to the more or less smooth surfaces, light cells in transverse arrangement and having inter-located surfaces on wide areas and spiral dark cells, located in transverse arrangement, with wider distances between them. (9) Under the influence of the progesterone, after the ovulation and during pregnancy, we may notice rare light cells, yet, the vacuolated cells dominate, especially after the ovulation. As well, typical spiral cells, with more or less smooth surfaces highlighted. At the level of the intrauterine connective tissue, although the predominant connective cell is the fibroblast, we may also notice macrophages, plasmocytes and masto- cytes, all these cell types being reduced in number. Both the structural appearance and the activity of the connective cells undergo changes that take place under the hormonal influences occurring in the uterine functional cycle. (2) We noticed that in the uterus that prepares for gestation, fibroblasts may undergo metaplasia and may change into myocytes. The pregnancy stresses the most the connective cell, in the sense of accelerating in it the synthesis process of the specific macromolecules, such as the collagen and certain products such as the glycosaminoglycanes. (3) The cervix of the adult woman presents in its structure a large amount of connective tissue, made up of cells, fibres, fundamental substance and a small number of smooth muscle fibres. In the non pregnancy stage, the connective of the cervix seems twice more abundant than the one uterine body. (4) The blood vessels of the myometrium, of artery or vein type, represent the constant and favourable element to all myomterial cell metabolic changes, in all the uterine functional phases. This way they insure all myometrial local metabolic activity, of synthesis, on collaboration between the myocytes and the surrounding connective, of cell symbiosis changing in pregnancy compared to non pregnancy. (6) On the myometrium fragments of the non pregnant Figure 3 Non pregnant normal uterus. Myometrium. Transmission Electron Microscopy x 2950 normal uterus and pregnant uterus at due time, by means of the classical histological technique we highlight an arrange ­ment characteristic to a myometrial area where the smooth muscle fibers are placed in fascicles having different direc ­tions and sizes. In between them, we may notice weakly represented connective structures, (fig. 1) The image shows a myometrial area where the connec ­tive structures are well represented in the non pregnant uterus. In the same time, we may notice that between the fascicules of myometrial muscle fibers, blood vessels of capillary and arterioles type are present in longitudinal section, (fig. 2) Figure 1 Non pregnant normal uterus. Myometrium. Optical Microscopy. Hematoxylin-Eosin stain x 20 Using the technique of electronic microscopy, on a microphoto we notice the detail of an area of the sarcoplasma of the uterine smooth muscle fiber. We notice a large number of mitochondria positioned in groups between the myofilaments and especially in a row in the closest neighborhood and along the dense bodies. Among Figure 4 Normal uterus, pregnant at due time. Myometrium. Optical Microscopy. Hematoxylin-Eosin stain x40 the mitochondria there are frequent glycogen inclusions. We may notice the anchoring of the actin filaments of the dense body of the myocyte, (fig. 3) At an magnifying power of 40x, using the classical histological technique, we observe the smooth muscle fibers, with elongated, euchromatic nucleus, with rich sarcoplasma and a cross-sectioned arteriole. The fibroblasts between the myocytes are rare, with dark, rectilinear nucleus, (fig. 4) The figure illustrates myocytes presenting a large, oval- shaped, largely elongated, rich in euchromatine nucleus, with 1-3 nucleoli. The sarcoplasma is abundant. Near the muscle fibers, there is a large amount of connective tissue with fibroblasts and numerous connective fibers, (fig. 5) Figure 2 Non pregnant normal uterus. Myometrium. Optical Microscopy. Van Gieson stain x 20 An observed ultrastructural aspect illustrates longitudi ­nally sectioned smooth muscle fibers, with grouped charac ­teristic arrangement, namely the thinned part of a myocyte being near the thicker central area of the neighboring myocytes. Between the muscle fibers there are narrow spaces with less connective matrix. The nucleus of the muscle fibers is predominantly euchromatic and the sarcoplasma near the poles of the nucleus contains cellular organelles, besides them we may observe myofilaments and rare dense odies. The sarcoplasma shows caveolae and dense areas, lear the myocytes we find a fibroblast with large nucleus, ctively euchromatic. Around it, the cytoplasm is loaded dth cellular organelles, among which we notice the rough ndoplasmic reticulum, as dilated, inter-communicating acks. (fig. 6) Researches based on modern techniques of electronic licroscopy, lead to data related to ultrastructural organization †¢f the uterine smooth muscle fibers, with its particularities in wo distinct functional moments, non pregnancy and regnancy, in healthy women, with uterus having no We observed the vicinity relations between the nyocytes and the connective cells at this level, focusing m the fibroblasts, connective cells considered to be lormone-sensitive, moreover as this type of cells takes  »art in the composition of organs that are hormone- ensitive such as the uterus or its components. (2) The technique of electronic microscopy highlighted dtrastructural aspects of the smooth muscle fibers, of the connective cells and of the vascular structures of the nyometrium of the non pregnant and pregnant uterus. Studies of electronic microscopy highlighted various tspects. Thus, the specific functions of the smooth muscle, uch as tension, contraction and relaxation, are considered to )e the result of the coordinated activity of the muscle cells. X/e assumed the existence of a functional syncytium at least or four functional conditions. In the same time, we lescribed the fusion of the neighboring cell membranes, in ;ertain contact points, namely intercellular junctions type  »nulla occludens and it may be considered that such ;onnections would represent the morphological fundamen- :als of the functional synctyium. (11) As well, we showed that :he number of noticed contact points is small compared to :he surface of the cell. According to certain authors, the iifferent forms of cell contacts are granted to various imctional states of the same muscle. The muscle connec- :ions thus exist as interdigital cells, on wide surfaces, with anclearly defined cell membranes or as sole, distinct cells. Varied forms of muscle cells seem to help the answer to the question whether the myometrial contraction is isotonic or isometric. From this point of view, we consider that the function of the myometrium resides in an isometric contraction. The observations of other researchers suggest that in the myometrium and in the smooth muscle of other cavity organs, the isometric and isotonic contractions are just different phases of a complex contraction cycle. According to the morphological observations, it seems to be the rhythmic passing from relaxation to isometric contractions and the other way around. (10) According to recent studies, the fine structure of myometrium from pigs collected at well-defined stages dur ­ing pregnancy was investigated by transmission electron microscopy. The morphology of the pregnant myometrium resembled that in non-pregnant pigs. Thick myofilaments were conspicuous during early pregnancy, unapparent during mid-pregnancy and visible again by days 80-84 and towards Figure 5 Normal uterus, pregnant at due time. Myometrium. Optical Microscopy. Van Gieson stain x20 Figure 6 Normal uterus, pregnant at due time. Myometrium. Transmission Electron Microscopy xl 500 parturition. Gap junctions were extremely rare throughout pregnancy. (8) The researches in the field are ongoing, due to the modern investigation possibilities that, besides the already known investigation methods, mainly refer to the immunohistochemical techniques.

Friday, October 25, 2019

Radio Waves :: essays research papers

Before beginning our research on radio waves, to us, radio waves were just waves going through the atmosphere, carrying sound from one place to another. Those were our ignorant days! We did not realize the complicated terms and theories involved. In the following report you will see how we advanced in our knowledge of radio waves, and we hope it will do the same for you. Radio waves are a combination of two kinds of electric vibrations. Audio frequency waves, which represent voice and other sounds and radio frequency waves, which carry audio waves after being combined with them. Two examples of broadcast waves are AM waves and FM waves. AM which stands for amplitude modulation, is a broadcasting method in which the carrier waves (carry the sounds of a program) are changed to match changes in the audio frequency waves. These are electric waves that represent the sounds of a radio broadcast. FM stands for frequency modulation and these waves, that go skyward, are not reflected. Instead, they pass through the atmosphere and go into space. AM signals, however, reflect off the atmosphere and travel back down to earth, causing broadcasts to be received at a much greater distance than FM signals. Since FM travels all the way to space and it does not bounce off the ground it does not create as much static as AM does. Radio waves, which travel at the speed of light, cannot be seen, heard, or felt in any way. When you listen to the radio, contrary to what some think, you are hearing the receivers pick up the waves and turn them into sound. Three more types of radio waves are; ground waves, ionospheric waves and tropospheric waves. Ground waves travel from the antenna along the surface of the earth. Ionospheric waves, otherwise known as sky waves, are made up of radio waves that come from a transmitting antenna and go into the sky. The ionosphere is the region of the rare field and ionized atmosphere around the earth, from 50 to 200 miles. Last but not least are the tropospheric waves. These waves are parts of the original wave which is reflected into the troposphere, an area of clouds and storms from 3 to 7 miles high. Radios change sound into electrical patterns with transmitters. In a radio transmitter, the circuit that generates the high frequency AC current that produces radio waves from an antenna, is called an oscillator. Electrical patterns are then changed into broadcast waves of electromagnetic energy. The Kenelly-Heairside layer, found in a transmission of a radio is now well known. This keeps the energy spent by a shortwave transmitter from escaping into space. This is why we are able

Thursday, October 24, 2019

Agribusiness

Agribusiness as a way of life Agribusiness for me is a systematic structure of well coordinated and oriented subsystems which makes the agriculture stable. Agribusiness can be viewed as a system, in which it compose of many subsystems. In agriculture where crops are cultivated to produce crops, the agribusiness plays an important role to distribute those crops in proper places at high value. Well, we all know that agriculture doesn't only involve in crops but also in poultry and livestock, fishery and forestry.It also plays an important role of the daily lives of the people, where the incessant interaction and circulation of commodities is discerned. Without Agribusiness, goods and services will not be delivered to various consumers and the needs and wants of the people cannot be attained. Agribusiness is tantamount to open system which composes of various subsystems. And in order for the system to be viable, its subsystem should also be viable. Any system has its own gaps and weakne sses that may lead the whole system to collapse.And it is obvious that to prevent the whole system to collapse, the operation of each and every subsystem should be well orchestrated, well coordinated and lastly well synchronized to make the whole system viable as it should be. By effective coordination and synergism, agribusiness as viable open system can be attained. The importance of agribusiness as a field of discipline is that we will discern the gaps and weaknesses of our career in which we could devise some individual developmental plan to improve ourselves as well mounded individual, highly competitive meeting national and global needs.Due to ineffable importance of agribusiness in people's daily lives. Many improvements were developed to make human needs, wants and activities much more accessible and easier leading to global industrialization. Annually, investments trends, prospects or development in agribusiness continuously devised to sustain domestic and global needs. The current investment trend or developments in Agribusiness is the â€Å"Biotech investment trend in Europe and Asia for 2012† in which it is stated that theE companies are finally following US and also Japanese organizations in improving their purchase in â€Å"agro-biotechnology' inside Asia. Although simply no precise figures can be obtained, estimates coming from different options indicate in which biotechnology purchase by E firms inside Asia provides increase coming from US dollars 230 million inside 1993 to be able to US dollar 270 thousand in 1995. The growing investment is combined with an increasing variety in business projects. (www. Investment-trend. Bloodspot. Com)

Wednesday, October 23, 2019

A Poison Apple Essay

In the poem ‘ A Poison Apple ‘, poet William Blake illustrates that how a person, angry with another. Through a variety of tropological element, Blake paints a picture of the angst of one individual directed toward his friend. First he uses hyperbole to emphasis the effect he has created. This is evident when he writes that his tears are causing the anger to grow between him and his friend. As written on line five and line six of stanza two, ‘And I watered it in fears Night and morning with my tears, ’. In reality, tears do not make things grow. In the poem though, Blake’s despair is growing more and more with each and very tear he sheds. The hyperbole continue with ‘ I told my wrath, my wrath did end. ’ and ‘ I told it not, my wrath did grow. ’ Wrath is something inside a person that cannot be grow like a tree. It is an emotion that people cannot always control. In the poem, Blake is showing that he can control it but in reality he cannot. That was the start of the anger to his friend. Last but not least, the way he grows the tree is a strong hyperbole to the way people do normally. ‘ And I sunned it with smiles ‘ and ‘ And with soft deceitful wiles. in line seven and line eight of stanza two, it described the way the author grow his anger and wrath. Trees should be grown in mud but Blake’s ‘ tree ’ was bombastically grown in soft deceitful wiles which is impossible to happen in real life. The anger of him was becoming more and more. William Blake does a masterful job of comparing the growth of a tree in garden to the growth in life. Unfortunately the tree that Blake is growing is a â€Å" poison tree †. If thrives on the anger and wrath of a friend, rather than on the love that should be considered. Most things grow better with love.